Main Article Content

Abstract

Purpose: A new series of benzodiazepine and benzothiazepine annulated derivatives of carbazolo condensed azepinones were synthesized. 


Methodology: Synthesis was done through a one-pot approach. The structure of these compounds was established based on their analytical IR, 1H NMR, 13C NMR and mass spectral data. The antimicrobial activity of the synthesized drugs was evaluated by the disc diffusion method.


Main Findings: The activity index and zone of inhibition were also examined in comparison to standard drugs fluconazole and streptomycin. The synthesized compound has gained much importance due to its diverse biological activities.


Implications: One-pot method is a highly innovative strategy, which has been easy to operate, requires inexpensive material and in applying to a wide range of functionalized substrates.

Keywords

Oxoketnedithioacetal Chalcone Friedel-Crafts Acylations Amino-substituted Carbazole Succinyl Chloride Derivatives Antimicrobial Activity

Article Details

How to Cite
Agrawal, M., Yadaw, G., Srivastava, A., & Jaiswal, S. (2022). Exceedingly simplistic one-pot protocol to the synthesis of [1, 5]-benzodiazepine and [1, 5]-benzothiazepine annulated derivatives of carbazolo condensed azepinones. Green Chemistry & Technology Letters, 8(1), 01-06. https://doi.org/10.18510/gctl.2022.811

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