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Uric acid, Prediabetes, diabetes, glycated haemoglobin, Uttrakhand, Uricase
Uric acid is considered to be an important risk factor for the development of type 2 diabetes mellitus (T2D) and a determinant of incidence of T2D in adults with glucose intolerance. There is conflicting finding regarding the trend of serum uric acid level in different glycemic status. Therefore this study has been aimed to investigate the association of serum uric acid level with glycemic parameters in prediabetic and diabetic individuals attending the tertiary care hospital in Uttarakhand,
An observational study was conducted in 721 individuals based on data collected from Biochemistry log book of AIIMS Rishikesh maintained from October 2014 to September 2016. The enzymatic method was carried out for measurement of Serum uric acid [ (Uricase) and blood glucose (BG) (Hexokinase)] level, and HbA1c was determined by immune inhibition method.
Out of 721 individuals (410 male and 311female) 118 and 504 individuals belonged to prediabetes and T2D respectively. Prediabetic individuals have higher uric acid level (5.408±1.7747 vs 5.639±1.7881) and diabetic individuals have significantly (p= 0.005) lower level of uric acid compared to healthy individuals (5.40±1.77 vs 5.12±1.53). Glycemic parameters showed positive association in normoglycemic individuals whereas significantly negative association in prediabetic and diabetic individuals. The ROC scatter plot revealed the area under the curve created by uric acid was 0.464 with 95% CI 0.399 - 0.530.
From this study it could be concluded that serum uric acid may be a determinant of altered glucose metabolism but not a potential predictor of prediabetes in north Indian populations residing in Uttarakhand.
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