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Abstract
Metformin hydrochloride is an oral antihyperglycemic drug used in the management of type-2 diabetes. Inclusion complexes were prepared between Metformin hydrochloride and alpha- cyclodextrin  in solid and solution state. Inclusion complexes were characterised using UV-VIS, Fluorescence and FTIR Spectroscopic Studies. Phase solubility studies were carried out which determined the 1:1 stoichiometry for the formation of inclusion complexes.
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References
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- Kavirajaa Pandian Sambasevam, Sharifah Mohamed, Norazilawati Muhamad Sarih and Nor Atiqah Ismail, Synthesis and Characterization of the Inclusion complex of β- Cyclodextrin and Azomethine, Int. J. Mol. Sci., 14, 2013, 3671-3682. DOI: https://doi.org/10.3390/ijms14023671
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References
Turro NJ, Okubo T & Chung C, Inclusional Association of a Fluorescence Detergent Probe with Cyclodextrins. Microscopic Environment of the interior of a Cyclodextrin Cavity. Pressure effects, J. Am. Chem. Soc., 104(14), 1982, 3954. DOI: https://doi.org/10.1021/ja00378a030
Hamai. S, Association of Inclusion Compounds of β- Cyclodextrin in Aqueous Solution, Bull. Chem. Soc. Jpn., 55, 1982, 2721. DOI: https://doi.org/10.1246/bcsj.55.2721
Valerian T. D’ Souza. Kenny B. Lipkowitz, Cyclodextrins: Introduction, Chem. Rev., 98(5), 1998, 1741. DOI: https://doi.org/10.1021/cr980027p
Uekama K, Hirayama F, Irie T, Chem. Rev., 98(5), 1998, 2045. DOI: https://doi.org/10.1021/cr970025p
Huang Naiju, You Chen, Zhang Daodao, Application of Cyclodextrin Inorganic Synthesis, Chin. J. Org. Chem., 6, 1987, 482.
Higuchi. T. Connors K, Phase-Solubility Techniques, Adv. Anal. Chem. Instr., 4, 1965, 212–217.
Yapeng Lu, Siyuan Liu, Yu, Zhao, Li Zhu, Shuqin Yu, Complexation of Z-ligustilide with hydroxypropyl-β- Cyclodextrin to improve stability and oral bioavailability, Acta. Pharm., 64, 2014, 211-222. DOI: https://doi.org/10.2478/acph-2014-0012
Benesi. H. A, Hildebrand J. H., The Benesi-Hildebrand Method for Determination of Kf for DA association and ε values for DA CT absorption, J. Am. Soc., 71, 1949, 2703. DOI: https://doi.org/10.1021/ja01176a030
Wang H.Y, Han J, Feng X.G, Spectroscopic study of Orange G-alpha-Cyclodextrin complex and its Analytical Applications, Spectrochim. Acta. A 66, 2007, 578–585. DOI: https://doi.org/10.1016/j.saa.2006.03.035
Wieslawa Misiuk, Spectrofluorimetric Study on Inclusion Interaction of β- Cyclodextrin with duloxetine and its analytical application, Ind. J. Chem., 51A 2012, 1706-1710.
Li. N, Liu. J, Zhao. X, Gao. Y, Zhang. L, Yu. L, Complex formation of ionic liquid surfactanct an alpha-Cyclodextrin, Colloids Surf. A, 292, 2007, 196-201. DOI: https://doi.org/10.1016/j.colsurfa.2006.06.023
Li. W, Lu. B; Sheng. A, Yang. F, Wang. Z, Spectrscopic and theoretical study on inclusion complexation of β- Cyclodextrin with Permethrin, J. Mol. Struct. 981, 2010, 194-203. DOI: https://doi.org/10.1016/j.molstruc.2010.08.008
Kavirajaa Pandian Sambasevam, Sharifah Mohamed, Norazilawati Muhamad Sarih and Nor Atiqah Ismail, Synthesis and Characterization of the Inclusion complex of β- Cyclodextrin and Azomethine, Int. J. Mol. Sci., 14, 2013, 3671-3682. DOI: https://doi.org/10.3390/ijms14023671
Ramnik Singh et al., Characterization of Cyclodextrin Inclusion Complexes-A Review, J. Pharm. Sci & Tech., 2(3), 2010, 171-183.
Mukesh Chandra Sharma & Smita Sharma., Preparation Physiochemical Characterization Dissolution Formulation and Spectroscopic Studies of β- Cyclodextrin Inclusion Complex, Int. J. Chem. Tech. Res., 3(1), 2011, 104-111.