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September 26, 2015
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September 26, 2015
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September 26, 2015
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Abstract

QSAR studies were performed on a series of delta 9-THC analogues have been analyzed in relation to their physicochemical and molecular properties. The activities of the compounds were found to be significantly correlated with the physicochemical parameters such as index of refraction (Ior) , equalized electro-negativity (Xeq), first, second and third order of connectivity indices (1c,2c,3c) and Mean weiner Index (WA). It was found that the presence of –OH group at R1 position was conducive for the inhibitory activity. The results are critically discussed on the basis of regression data and cross validation techniques. Poglani factor Q and the results of LOO (leave one out) method confirms the reliability and predictability of the proposed models.

Keywords

QSAR cannabinoid receptor modulators physicochemical property regression analysis LOO.

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Shukla, N. (2015). QSAR STUDIES ON A SERIES OF (delta) 9-THC ANALOGUES AS CANNABINOID RECEPTOR MODULATORS. International Journal of Students’ Research in Technology & Management, 2(1), 29–36. Retrieved from https://mgesjournals.com/ijsrtm/article/view/115
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