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The influence of obesity on the risk of development of selected gastrointestinal cancers
Corresponding Author(s) : Anita Marcinkiewicz
Humanities & Social Sciences Reviews,
Vol. 11 No. 4 (2023): July
Abstract
Purpose of the study: The subject of consideration is the influence of obesity on gastrointestinal cancers. Considerations were focused on discussing the connection between obesity and the risk of cancer of particular organs of the gastrointestinal tract. The aim of the work is to analyze this phenomenon and to show the connection between these two issues.
Methodology: The article was prepared with the use the critical literature review method. Appropriate materials focused on the subject of consideration were searched, among others, in PubMed and specialized literature.
Main conclusions: The analyzes of available materials show that obesity significantly affects the occurrence of gastrointestinal cancers, and also affects the treatment and prognosis of cancer patients. It predisposes not only to gastrointestinal cancers, which are the subject of this article, but also to other cancers, which is worth emphasizing.
Applied studies: The article shows the broad influence of obesity on particular gastrointestinal cancers. The content contained in the article can be useful for doctors to systematize knowledge, but also for patients to make them aware and motivate them to change and a healthier lifestyle.
Originality of research: The report presents medical knowledge in an accessible way, making it easier to assimilate. It allows to understand the problem of obesity and its impact on the incidence of gastrointestinal cancers. It may also inspire further research on this issu.
Keywords
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- Abdallah, J., Maradeyâ€Romero, C., Lewis, S., Perzynski, A., & Fass, R. (2015). The relationship between length of Barrett's oesophagus mucosa and body mass index. Alimentary Pharmacology & Therapeutics, 41(1), 137-144. https://doi.org/10.1111/apt.12991 DOI: https://doi.org/10.1111/apt.12991
- Astrup, A., Gøtzsche, P. C., van de Werken, K., Ranneries, C., Toubro, S., Raben, A., & Buemann, B. (1999). Meta-analysis of resting metabolic rate in formerly obese subjects. The American journal of clinical nutrition, 69(6), 1117-1122. https://doi.org/10.1093/ajcn/69.6.1117 DOI: https://doi.org/10.1093/ajcn/69.6.1117
- Bardou, M., Barkun, A.N., & Martel, M. (2013). Obesity and colorectal cancer, Gut, 62(6):933-47. https://doi.org/10.1136/gutjnl-2013-304701 DOI: https://doi.org/10.1136/gutjnl-2013-304701
- Bell, J. A., Hamer, M., van Hees, V. T., Singh-Manoux, A., Kivimäki, M., & Sabia, S. (2015). Healthy obesity and objective physical activity. The American journal of clinical nutrition, 102(2), 268-275. https://doi.org/10.3945/ajcn.115.110924 DOI: https://doi.org/10.3945/ajcn.115.110924
- Binkowska-Borgosz, I., Starzyńska, T., & Błogowski, W. (2014). Otyłość a nowotwory przewodu pokarmowego. Postępy Higieny i Medycyny Doświadczalnej, 68, 1193-1198. https://doi.org/10.5604/17322693.1125648 DOI: https://doi.org/10.5604/17322693.1125648
- Brończyk-Puzoń, A., Koszowska, A., Nowak, J., Dittfeld, A., & Bieniek, J. (2014). Epidemiologia otyłości na świecie iw Polsce. Forum Zaburzeń Metabolicznych, 5(1).
- Caldwell, S.H., Crespo, D.M., Kang, H.S., & Al-Osaimi, A.M.S. 2004. Obesity and hepatocellular carcinoma; Gastroenterology. Nov;127(5 Suppl 1), S97-103. https://doi.org/10.1053/j.gastro.2004.09.021 DOI: https://doi.org/10.1053/j.gastro.2004.09.021
- Clements, O., Eliahoo, J., Jin Un, K., Taylor-Robinson, S.D., & Shahid, A.K. (2020). Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: A systematic review and meta-analysis, Journal of Hepatology, Jan;72(1),95-103. https://doi.org/10.1016/j.jhep.2019.09.007 DOI: https://doi.org/10.1016/j.jhep.2019.09.007
- Crovesy, L., Masterson, D., & Rosado, E.L., (2020). Profile of the gut microbiota of adults with obesity: a systematic review. European Journal of Clinical Nutrition, 74(9),1251-1262. https://doi.org/10.1038/s41430-020-0607-6 DOI: https://doi.org/10.1038/s41430-020-0607-6
- Ćwiklińska-Dworakowska, M., Szymczuk, J., & Pogorzelski, G., (2017). Przypadek raka pęcherzyka żółciowego -materiał własny, Chirurgia Polska, 19(1–2), 41–43.
- Donohoe, C.L., Pidgeon, Lysaght J., & Reynolds J.V. (2010). Obesity and gastrointestinal cancer, British Journal of Surgery, 97(5), 628–642. https://doi.org/10.1002/bjs.7079 DOI: https://doi.org/10.1002/bjs.7079
- Donohoe, F., Wilkinson, M., Baxter, E., & Brennan, D.J., (2020). Mitogen-Activated Protein Kinase (MAPK) and Obesity-Related Cancer, International Journal of Molecular Sciences, 21(4), 1241. https://doi.org/10.3390/ijms21041241 DOI: https://doi.org/10.3390/ijms21041241
- Gethings-Behncke, C., Coleman, H.G., Jordao, H.W.T., Longley, D.B., Crawford, N., Murray, L.J., & Kunzmann, A.T. (2020). Fusobacterium nucleatum in the colorectum and its association with cancer risk and survival: a systematic review and meta-analysis. Cancer Epidemiology, Biomarkers and Prevention, 29, 539–548. https://doi.org/10.1158/1055-9965.EPI-18-1295 DOI: https://doi.org/10.1158/1055-9965.EPI-18-1295
- Ghidini, M., Ramai, D., Facciorusso, A., Singh, J., Tai, W., Rijavec, E., Galassi, B., Grossi, F., & Indini, A. (2021). Metabolic disorders and the risk of cholangiocarcinoma, Expert Review of Gastroenterology & Hepatology, 15(9),999-1007. https://doi.org/10.1080/17474124.2021.1946393 DOI: https://doi.org/10.1080/17474124.2021.1946393
- Giovannucci, E. (2001). Insulin, insulin-like growth factors and colon cancer: a review of the evidence. The Journal of Nutrition, 131(11 Suppl), 3109S-20S. https://doi.org/10.1093/jn/131.11.3109S DOI: https://doi.org/10.1093/jn/131.11.3109S
- Haydon, A.M., Macinnis, R.J., English, D.R., & Giles, G.G. (2006). Effect of physical activity and body size on survival after diagnosis with colorectal cancer. Gut, 55, 62–67. https://doi.org/10.1136/gut.2005.068189 DOI: https://doi.org/10.1136/gut.2005.068189
- Hillon, P., Guiu, B., Vincent, J., & Petit, J-M. (2010). Obesity, type 2 diabetes and risk of digestive cancer. Gastroenterologie Clinique et Biologique, 34(10), 529-33. https://doi.org/10.1016/j.gcb.2010.07.021 DOI: https://doi.org/10.1016/j.gcb.2010.07.021
- Hoyo, C., Cook, M.B., & Kamangar, F. (2012). Body mass index in relation to oesophageal and oesophagogastric junction adenocarcinomas: a pooled analysis from the International BEACON Consortium. Int J Epidemiol; 41(6), 1706-1718. https://doi.org/10.1093/ije/dys176 DOI: https://doi.org/10.1093/ije/dys176
- Jochem, C., & Leitzmann, M. (2018). Obesity and Colorectal cancer, Recent Results Cancer Research, 208,17-41. https://doi.org/10.1007/978-3-319-42542-9_2 DOI: https://doi.org/10.1007/978-3-319-42542-9_2
- Klein, S., Wadden, T., & Sugerman, H.J. (2002). AGA technical review on obesity. American Gastroenterological Association, 123(3), 882-932. https://doi.org/10.1053/gast.2002.35514 DOI: https://doi.org/10.1053/gast.2002.35514
- Korek, E., & Krauss, H. (2015). Nowe adipokiny o potencjalnym znaczeniu w patogenezie otyłości i zaburzeń metabolicznych, Postępy Higieny i Medycyny Doświadczalnej, 69, 799-810. https://doi.org/10.5604/17322693.1161415 DOI: https://doi.org/10.5604/17322693.1161415
- Krawczyk, M., Wasilewicz, M., Hartleb, M., Krzakowski, M., Milkiewicz, P., Habior, A., Górnicka, B., Cierpka, L., Król, R., Cichoż-Lach, H., & Raszeja-Wyszomirska, J. (2016). Rozpoznawanie i leczenie raka wątrobowokomórkowego — rekomendacje Sekcji Hepatologicznej Polskiego Towarzystwa Gastroenterologii; Gastroenterologia Praktyczna, tom VIII, 1 (30).
- Kuipers, E.J., Grady, W.M., Lieberman, D., Seufferlein, T., Sung, J.J., Boelens, P.G., van de Velde, C.J.H., & Watanabe, T. (2016). Colorectal Cancer, Nature Reviews Disease Primers., 1, 15065. https://doi.org/10.1038/nrdp.2015.65 DOI: https://doi.org/10.1038/nrdp.2015.65
- Lagergren, J. (2011). Influence of obesity on the risk of esophageal disorders. Nature reviews. Gastroenterology & hepatology, 8(6), 340–347. https://doi.org/10.1038/nrgastro.2011.73 DOI: https://doi.org/10.1038/nrgastro.2011.73
- Larsson, S.C., & Wolk, A. (2007). Obesity and the risk of gallbladder cancer: a meta-analysis, British Journal of Cancer, 96, 1457-1461. https://doi.org/10.1038/sj.bjc.6603703 DOI: https://doi.org/10.1038/sj.bjc.6603703
- Li, D., Morris, J.S., Liu, J., Hassan, M.M., Day, R.S., Bondy, M.L., & Abbruzzese, J.L. (2009). Body mass index and risk, age of onset, and survival in patients with pancreatic cancer. JAMA, 301(24), 2553–2562. https://doi.org/10.1001/jama.2009.886 DOI: https://doi.org/10.1001/jama.2009.886
- Li, R., Grimm, S.A., Mav, D., Go, H., Djukovic, D., Shah, R., Merrick, B.A., Raftery, D., & Wade, P.A. (2018). Transcriptome and DNA Methylome Analysis in a Mouse Model of Diet-Induced Obesity Predicts Increased Risk of Colorectal Cancer. Cell Reports,22(3), 624–37. https://doi.org/10.1016/j.celrep.2017.12.071 DOI: https://doi.org/10.1016/j.celrep.2017.12.071
- Maciejewska-Cebulak, M. (2017). Wpływ nadwagi i otyłości na powstawanie nowotworów, Forum Medycyny Rodzinnej 2017, tom 11, nr 2, 73–79.
- MacInnis, R. J., English, D. R., Hopper, J. L., & Giles, G. G. (2006). Body size and composition and the risk of gastric and oesophageal adenocarcinoma. International journal of cancer, 118(10), 2628–2631. https://doi.org/10.1002/ijc.21638 DOI: https://doi.org/10.1002/ijc.21638
- Mandeville, Y., Van Looveren, R., Vancoillie, P. J., Verbeke, X., Vandendriessche, K., Vuylsteke, P., Pattyn, P., & Smet, B. (2017). Moderating the Enthusiasm of Sleeve Gastrectomy: Up to Fifty Percent of Reflux Symptoms After Ten Years in a Consecutive Series of One Hundred Laparoscopic Sleeve Gastrectomies. Obesity surgery, 27(7), 1797–1803. https://doi.org/10.1007/s11695-017-2567-z DOI: https://doi.org/10.1007/s11695-017-2567-z
- Meyerhardt, J.A., Catalano, P.J., Haller, D.G., Mayer, R.J., Benson, A.B., & Macdonald, J.S. (2003). Influence of body mass index on outcomes and treatment-related toxicity in patients with colon carcinoma, Cancer, 98, 484–495. https://doi.org/10.1002/cncr.11544 DOI: https://doi.org/10.1002/cncr.11544
- Moore, L.L., Bradlee M.L., Singer M.R., Splansky G.L., Proctor M.H., Ellison R.C., & Kreger, B.E. (2004). BMI and waist circumference as predictors of lifetime colon cancer risk in Framingham Study adults. International Journal of Obesity, 28, 559–567. https://doi.org/10.1038/sj.ijo.0802606 DOI: https://doi.org/10.1038/sj.ijo.0802606
- Nam, S.Y. (2017). Obesity-Related Digestive Diseases and Their Pathophysiology, Gut and Liver, 11(3),323-334. https://doi.org/10.5009/gnl15557 DOI: https://doi.org/10.5009/gnl15557
- Osataphan, S., Mahankasuwan, T., & Saengboonmee, C. (2021). Obesity and cholangiocarcinoma: A review of epidemiological and molecular associations, Journal of Hepato- biliary- pancreatic Sciences, 28(12),1047-1059. https://doi.org/10.1002/jhbp.1001 DOI: https://doi.org/10.1002/jhbp.1001
- Parida, S., Siddharth, S., & Sharma, D. (2019). Adiponectin, Obesity, and Cancer: Clash of the Bigwigs in Health and Disease. International Journal of Molecular Sciences, 20(10),2519. https://doi.org/10.3390/ijms20102519 DOI: https://doi.org/10.3390/ijms20102519
- Pischon, T., Boeing, H., & Hoffmann, K. (2008). General and abdominal adiposity and risk of death in Europe, The New England Journal of Medicine, 359, 2105–2120.
- Poczęta, M., & Bednarek, I. (2013). STAT3–ukryty czynnik transkrypcyjny celem terapii przeciwnowotworowych. In Annales Academiae Medicae Silesiensis, 67(2).
- Poorolajal, J., Moradi, L., Mohammadi, Y., Cheraghi, Z., Gohari-Ensaf, F. (2020). Risk factors for stomach cancer: a systematic review and meta-analysis. Epidemiol Health, 42, e2020004. https://doi.org/10.4178/epih.e2020004 DOI: https://doi.org/10.4178/epih.e2020004
- Pothuraju, R., Rachagani, S., Junker, W.M., Chaudhary, S., Saraswathi, V., Kaur, S., Batra, S.K., (2018). Pancreatic cancer associated with obesity and diabetes: an alternative approach for its targeting, Journal of Experimental & Clinical Cancer Research 37, Article number: 319. https://doi.org/10.1186/s13046-018-0963-4 DOI: https://doi.org/10.1186/s13046-018-0963-4
- Preziosi, G., Oben, J.A., Fusai, G. (2014). Obesity and pancreatic cancer, Surgical Oncology, 23(2),61-71. https://doi.org/10.1016/j.suronc.2014.02.003 DOI: https://doi.org/10.1016/j.suronc.2014.02.003
- Renehan, A.G., Tysona, M., Egger, M., Halerz, R.F., & Zwahlen, M. (2008). Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet, 371, 569–578. https://doi.org/10.1016/S0140-6736(08)60269-X DOI: https://doi.org/10.1016/S0140-6736(08)60269-X
- Saitta, C., Pollicino, T., & Raimondo, G. (2019). Obesity and liver cancer. Annals of Hepatology, 18(6), 810-815. https://doi.org/10.1016/j.aohep.2019.07.004 DOI: https://doi.org/10.1016/j.aohep.2019.07.004
- Sánchez-Alcoholado, L., Ordóñez, R., Otero, A., Plaza-Andrade, I., Laborda-Illanes, A., Medina, J.A., Ramos-Molina, B., Gómez-Millán, J., & Queipo-Ortuño, M.I. (2020). Gut MicrobiotaMediated Inflammation and Gut Permeability in Patients with Obesity and Colorectal Cancer. International Journal of Molecular Sciences, 21(18), 6782. https://doi.org/10.3390/ijms21186782 DOI: https://doi.org/10.3390/ijms21186782
- Schlottmann, F., Dreifuss, N. H., & Patti, M. G. (2020). Obesity and esophageal cancer: GERD, Barrett´s esophagus, and molecular carcinogenic pathways. Expert Review of Gastroenterology & Hepatology, 14(6), 425–433. https://doi.org/10.1080/17474124.2020.1764348 DOI: https://doi.org/10.1080/17474124.2020.1764348
- Singh, S., Sharma, A. N., Murad, M. H., Buttar, N. S., El-Serag, H. B., Katzka, D. A., & Iyer, P. G. (2013). Central adiposity is associated with increased risk of esophageal inflammation, metaplasia, and adenocarcinoma: a systematic review and meta-analysis. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association, 11(11), 1399–1412.e7. https://doi.org/10.1016/j.cgh.2013.05.009 DOI: https://doi.org/10.1016/j.cgh.2013.05.009
- Socol, C.T., Chira, A., Martinez-Sanchez, M.A., Nuñez-Sanchez, M.A., Maerescu, C.M., Mierlita, D., Rusu, A.V., Ruiz-Alcaraz, A.J., Trif, M., & Ramos-Molina, B. (2022). International Journal of Molecular Sciences, 23(9), 4713. https://doi.org/10.3390/ijms23094713 DOI: https://doi.org/10.3390/ijms23094713
- Stevens, G.A., Singh, G.M., Lu, Y., Danaei, G., Lin, J.K., Finucane, M.M., Bahalim, A.N., McIntire, R.K., Gutierrez, H.R., Cowan, M., Paciorek, C.J., Farzadfar, F., Riley, L., & Ezzati, M. (2012). National, regional, and global trends in adult overweight and obesity prevalences. Population Health Metrics, 10(1), 22. https://doi.org/10.1186/1478-7954-10-22 DOI: https://doi.org/10.1186/1478-7954-10-22
- Szczeklik, A., & Gajewski, P. (2020). Interna Szczeklika 2020, Kraków: MP, 1148-1152.
- Vainio, H, Bianchini, F., & Vainio, H. (2002) Weight Control and Physical Activity, Obesity Reviews: an official journal of the International Association for the Study of Obesity, 3(1), 5-8. https://doi.org/10.1046/j.1467-789X.2002.00046.x DOI: https://doi.org/10.1046/j.1467-789X.2002.00046.x
- Van Gaal, L.F, Mertens, I.L, & De Block, C.E. (2006). Mechanisms linking obesity with cardiovascular disease. Nature, 444, 875–880. https://doi.org/10.1038/nature05487 DOI: https://doi.org/10.1038/nature05487
- Vigneri, P.G., Tirrò, E., Pennisi,, M.S., Massimino, M., Stella, S., Romano, C., & Manzella, L. (2015). The Insulin/IGF System in Colorectal Cancer Development and Resistance to Therapy, Frontiers in Oncology, 15(5), 230. https://doi.org/10.3389/fonc.2015.00230 DOI: https://doi.org/10.3389/fonc.2015.00230
- Vucenik, I., & Joseph, P.S. (2012). Obesity and cancer risk: evidence, mechanisms, and recommendations, The New York Academy of Sciences. https://doi.org/10.1111/j.1749-6632.2012.06750.x DOI: https://doi.org/10.1111/j.1749-6632.2012.06750.x
- Wang, T., Cai, G., Qiu, Y., Fei, N., Zhang, M., Pang, X., Jia, W., Cai, S., & Zhao, L. (2012). Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers. The ISME Journal, 6(2),320–329. https://doi.org/10.1038/ismej.2011.109 DOI: https://doi.org/10.1038/ismej.2011.109
- Wojciechowska, U., Barańska, K., Michałek, I., Olasek, P., Miklewska, M., & Didkowska, J.A. (2022). Nowotwory złośliwe w Polsce w 2020 roku, Narodowy Instytut Onkologii im. Marii Curie- Skłodowskiej. Państwowy Instytut Badawczy., Krajowy rejestr nowotworów, 44-45.
- World Health Organization (2009). Global health risks: mortality and burden of disease attributable to selected major risks. Geneva: World Health Organization.
- Xu, M., Jung, X., Hines, O.J., M.D., Eibl, G., & Chen, Y. (2018). Obesity and Pancreatic Cancer: Overview of Epidemiology and Potential Prevention by Weight Loss, Pancreas, 47(2), 158–162. https://doi.org/10.1097/MPA.0000000000000974 DOI: https://doi.org/10.1097/MPA.0000000000000974
- Yang, J., Ji, N., Xuelei, M., Yuquan, W., Yong, P., Xiawei, W. (2019). Targeting PI3K in cancer: mechanisms and advances in clinical trials, Molecular Cancer, 18, Article number: 26. https://doi.org/10.1186/s12943-019-0954-x DOI: https://doi.org/10.1186/s12943-019-0954-x
- Zhang R., Li, H., Li, N. (2021). Risk factors for gastric cancer: a large-scale, population-based case-control study. Chin Med J (Engl), 134(16), 1952-1958. https://doi.org/10.1097/CM9.0000000000001652 DOI: https://doi.org/10.1097/CM9.0000000000001652
- Zhang, Y. (2013). Epidemiology of esophageal cancer. World journal of gastroenterology, 19(34), 5598–5606. https://doi.org/10.3748/wjg.v19.i34.5598 DOI: https://doi.org/10.3748/wjg.v19.i34.5598
- Zieliński, J. (2012). Chorobliwa otyłość jako przyczyna niewydolności oddychania, Pneumonologia i Alergologia Polska 2012, tom 80, nr 6, 555–559. https://doi.org/10.5603/ARM.27543 DOI: https://doi.org/10.5603/ARM.27543
References
Abdallah, J., Maradeyâ€Romero, C., Lewis, S., Perzynski, A., & Fass, R. (2015). The relationship between length of Barrett's oesophagus mucosa and body mass index. Alimentary Pharmacology & Therapeutics, 41(1), 137-144. https://doi.org/10.1111/apt.12991 DOI: https://doi.org/10.1111/apt.12991
Astrup, A., Gøtzsche, P. C., van de Werken, K., Ranneries, C., Toubro, S., Raben, A., & Buemann, B. (1999). Meta-analysis of resting metabolic rate in formerly obese subjects. The American journal of clinical nutrition, 69(6), 1117-1122. https://doi.org/10.1093/ajcn/69.6.1117 DOI: https://doi.org/10.1093/ajcn/69.6.1117
Bardou, M., Barkun, A.N., & Martel, M. (2013). Obesity and colorectal cancer, Gut, 62(6):933-47. https://doi.org/10.1136/gutjnl-2013-304701 DOI: https://doi.org/10.1136/gutjnl-2013-304701
Bell, J. A., Hamer, M., van Hees, V. T., Singh-Manoux, A., Kivimäki, M., & Sabia, S. (2015). Healthy obesity and objective physical activity. The American journal of clinical nutrition, 102(2), 268-275. https://doi.org/10.3945/ajcn.115.110924 DOI: https://doi.org/10.3945/ajcn.115.110924
Binkowska-Borgosz, I., Starzyńska, T., & Błogowski, W. (2014). Otyłość a nowotwory przewodu pokarmowego. Postępy Higieny i Medycyny Doświadczalnej, 68, 1193-1198. https://doi.org/10.5604/17322693.1125648 DOI: https://doi.org/10.5604/17322693.1125648
Brończyk-Puzoń, A., Koszowska, A., Nowak, J., Dittfeld, A., & Bieniek, J. (2014). Epidemiologia otyłości na świecie iw Polsce. Forum Zaburzeń Metabolicznych, 5(1).
Caldwell, S.H., Crespo, D.M., Kang, H.S., & Al-Osaimi, A.M.S. 2004. Obesity and hepatocellular carcinoma; Gastroenterology. Nov;127(5 Suppl 1), S97-103. https://doi.org/10.1053/j.gastro.2004.09.021 DOI: https://doi.org/10.1053/j.gastro.2004.09.021
Clements, O., Eliahoo, J., Jin Un, K., Taylor-Robinson, S.D., & Shahid, A.K. (2020). Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: A systematic review and meta-analysis, Journal of Hepatology, Jan;72(1),95-103. https://doi.org/10.1016/j.jhep.2019.09.007 DOI: https://doi.org/10.1016/j.jhep.2019.09.007
Crovesy, L., Masterson, D., & Rosado, E.L., (2020). Profile of the gut microbiota of adults with obesity: a systematic review. European Journal of Clinical Nutrition, 74(9),1251-1262. https://doi.org/10.1038/s41430-020-0607-6 DOI: https://doi.org/10.1038/s41430-020-0607-6
Ćwiklińska-Dworakowska, M., Szymczuk, J., & Pogorzelski, G., (2017). Przypadek raka pęcherzyka żółciowego -materiał własny, Chirurgia Polska, 19(1–2), 41–43.
Donohoe, C.L., Pidgeon, Lysaght J., & Reynolds J.V. (2010). Obesity and gastrointestinal cancer, British Journal of Surgery, 97(5), 628–642. https://doi.org/10.1002/bjs.7079 DOI: https://doi.org/10.1002/bjs.7079
Donohoe, F., Wilkinson, M., Baxter, E., & Brennan, D.J., (2020). Mitogen-Activated Protein Kinase (MAPK) and Obesity-Related Cancer, International Journal of Molecular Sciences, 21(4), 1241. https://doi.org/10.3390/ijms21041241 DOI: https://doi.org/10.3390/ijms21041241
Gethings-Behncke, C., Coleman, H.G., Jordao, H.W.T., Longley, D.B., Crawford, N., Murray, L.J., & Kunzmann, A.T. (2020). Fusobacterium nucleatum in the colorectum and its association with cancer risk and survival: a systematic review and meta-analysis. Cancer Epidemiology, Biomarkers and Prevention, 29, 539–548. https://doi.org/10.1158/1055-9965.EPI-18-1295 DOI: https://doi.org/10.1158/1055-9965.EPI-18-1295
Ghidini, M., Ramai, D., Facciorusso, A., Singh, J., Tai, W., Rijavec, E., Galassi, B., Grossi, F., & Indini, A. (2021). Metabolic disorders and the risk of cholangiocarcinoma, Expert Review of Gastroenterology & Hepatology, 15(9),999-1007. https://doi.org/10.1080/17474124.2021.1946393 DOI: https://doi.org/10.1080/17474124.2021.1946393
Giovannucci, E. (2001). Insulin, insulin-like growth factors and colon cancer: a review of the evidence. The Journal of Nutrition, 131(11 Suppl), 3109S-20S. https://doi.org/10.1093/jn/131.11.3109S DOI: https://doi.org/10.1093/jn/131.11.3109S
Haydon, A.M., Macinnis, R.J., English, D.R., & Giles, G.G. (2006). Effect of physical activity and body size on survival after diagnosis with colorectal cancer. Gut, 55, 62–67. https://doi.org/10.1136/gut.2005.068189 DOI: https://doi.org/10.1136/gut.2005.068189
Hillon, P., Guiu, B., Vincent, J., & Petit, J-M. (2010). Obesity, type 2 diabetes and risk of digestive cancer. Gastroenterologie Clinique et Biologique, 34(10), 529-33. https://doi.org/10.1016/j.gcb.2010.07.021 DOI: https://doi.org/10.1016/j.gcb.2010.07.021
Hoyo, C., Cook, M.B., & Kamangar, F. (2012). Body mass index in relation to oesophageal and oesophagogastric junction adenocarcinomas: a pooled analysis from the International BEACON Consortium. Int J Epidemiol; 41(6), 1706-1718. https://doi.org/10.1093/ije/dys176 DOI: https://doi.org/10.1093/ije/dys176
Jochem, C., & Leitzmann, M. (2018). Obesity and Colorectal cancer, Recent Results Cancer Research, 208,17-41. https://doi.org/10.1007/978-3-319-42542-9_2 DOI: https://doi.org/10.1007/978-3-319-42542-9_2
Klein, S., Wadden, T., & Sugerman, H.J. (2002). AGA technical review on obesity. American Gastroenterological Association, 123(3), 882-932. https://doi.org/10.1053/gast.2002.35514 DOI: https://doi.org/10.1053/gast.2002.35514
Korek, E., & Krauss, H. (2015). Nowe adipokiny o potencjalnym znaczeniu w patogenezie otyłości i zaburzeń metabolicznych, Postępy Higieny i Medycyny Doświadczalnej, 69, 799-810. https://doi.org/10.5604/17322693.1161415 DOI: https://doi.org/10.5604/17322693.1161415
Krawczyk, M., Wasilewicz, M., Hartleb, M., Krzakowski, M., Milkiewicz, P., Habior, A., Górnicka, B., Cierpka, L., Król, R., Cichoż-Lach, H., & Raszeja-Wyszomirska, J. (2016). Rozpoznawanie i leczenie raka wątrobowokomórkowego — rekomendacje Sekcji Hepatologicznej Polskiego Towarzystwa Gastroenterologii; Gastroenterologia Praktyczna, tom VIII, 1 (30).
Kuipers, E.J., Grady, W.M., Lieberman, D., Seufferlein, T., Sung, J.J., Boelens, P.G., van de Velde, C.J.H., & Watanabe, T. (2016). Colorectal Cancer, Nature Reviews Disease Primers., 1, 15065. https://doi.org/10.1038/nrdp.2015.65 DOI: https://doi.org/10.1038/nrdp.2015.65
Lagergren, J. (2011). Influence of obesity on the risk of esophageal disorders. Nature reviews. Gastroenterology & hepatology, 8(6), 340–347. https://doi.org/10.1038/nrgastro.2011.73 DOI: https://doi.org/10.1038/nrgastro.2011.73
Larsson, S.C., & Wolk, A. (2007). Obesity and the risk of gallbladder cancer: a meta-analysis, British Journal of Cancer, 96, 1457-1461. https://doi.org/10.1038/sj.bjc.6603703 DOI: https://doi.org/10.1038/sj.bjc.6603703
Li, D., Morris, J.S., Liu, J., Hassan, M.M., Day, R.S., Bondy, M.L., & Abbruzzese, J.L. (2009). Body mass index and risk, age of onset, and survival in patients with pancreatic cancer. JAMA, 301(24), 2553–2562. https://doi.org/10.1001/jama.2009.886 DOI: https://doi.org/10.1001/jama.2009.886
Li, R., Grimm, S.A., Mav, D., Go, H., Djukovic, D., Shah, R., Merrick, B.A., Raftery, D., & Wade, P.A. (2018). Transcriptome and DNA Methylome Analysis in a Mouse Model of Diet-Induced Obesity Predicts Increased Risk of Colorectal Cancer. Cell Reports,22(3), 624–37. https://doi.org/10.1016/j.celrep.2017.12.071 DOI: https://doi.org/10.1016/j.celrep.2017.12.071
Maciejewska-Cebulak, M. (2017). Wpływ nadwagi i otyłości na powstawanie nowotworów, Forum Medycyny Rodzinnej 2017, tom 11, nr 2, 73–79.
MacInnis, R. J., English, D. R., Hopper, J. L., & Giles, G. G. (2006). Body size and composition and the risk of gastric and oesophageal adenocarcinoma. International journal of cancer, 118(10), 2628–2631. https://doi.org/10.1002/ijc.21638 DOI: https://doi.org/10.1002/ijc.21638
Mandeville, Y., Van Looveren, R., Vancoillie, P. J., Verbeke, X., Vandendriessche, K., Vuylsteke, P., Pattyn, P., & Smet, B. (2017). Moderating the Enthusiasm of Sleeve Gastrectomy: Up to Fifty Percent of Reflux Symptoms After Ten Years in a Consecutive Series of One Hundred Laparoscopic Sleeve Gastrectomies. Obesity surgery, 27(7), 1797–1803. https://doi.org/10.1007/s11695-017-2567-z DOI: https://doi.org/10.1007/s11695-017-2567-z
Meyerhardt, J.A., Catalano, P.J., Haller, D.G., Mayer, R.J., Benson, A.B., & Macdonald, J.S. (2003). Influence of body mass index on outcomes and treatment-related toxicity in patients with colon carcinoma, Cancer, 98, 484–495. https://doi.org/10.1002/cncr.11544 DOI: https://doi.org/10.1002/cncr.11544
Moore, L.L., Bradlee M.L., Singer M.R., Splansky G.L., Proctor M.H., Ellison R.C., & Kreger, B.E. (2004). BMI and waist circumference as predictors of lifetime colon cancer risk in Framingham Study adults. International Journal of Obesity, 28, 559–567. https://doi.org/10.1038/sj.ijo.0802606 DOI: https://doi.org/10.1038/sj.ijo.0802606
Nam, S.Y. (2017). Obesity-Related Digestive Diseases and Their Pathophysiology, Gut and Liver, 11(3),323-334. https://doi.org/10.5009/gnl15557 DOI: https://doi.org/10.5009/gnl15557
Osataphan, S., Mahankasuwan, T., & Saengboonmee, C. (2021). Obesity and cholangiocarcinoma: A review of epidemiological and molecular associations, Journal of Hepato- biliary- pancreatic Sciences, 28(12),1047-1059. https://doi.org/10.1002/jhbp.1001 DOI: https://doi.org/10.1002/jhbp.1001
Parida, S., Siddharth, S., & Sharma, D. (2019). Adiponectin, Obesity, and Cancer: Clash of the Bigwigs in Health and Disease. International Journal of Molecular Sciences, 20(10),2519. https://doi.org/10.3390/ijms20102519 DOI: https://doi.org/10.3390/ijms20102519
Pischon, T., Boeing, H., & Hoffmann, K. (2008). General and abdominal adiposity and risk of death in Europe, The New England Journal of Medicine, 359, 2105–2120.
Poczęta, M., & Bednarek, I. (2013). STAT3–ukryty czynnik transkrypcyjny celem terapii przeciwnowotworowych. In Annales Academiae Medicae Silesiensis, 67(2).
Poorolajal, J., Moradi, L., Mohammadi, Y., Cheraghi, Z., Gohari-Ensaf, F. (2020). Risk factors for stomach cancer: a systematic review and meta-analysis. Epidemiol Health, 42, e2020004. https://doi.org/10.4178/epih.e2020004 DOI: https://doi.org/10.4178/epih.e2020004
Pothuraju, R., Rachagani, S., Junker, W.M., Chaudhary, S., Saraswathi, V., Kaur, S., Batra, S.K., (2018). Pancreatic cancer associated with obesity and diabetes: an alternative approach for its targeting, Journal of Experimental & Clinical Cancer Research 37, Article number: 319. https://doi.org/10.1186/s13046-018-0963-4 DOI: https://doi.org/10.1186/s13046-018-0963-4
Preziosi, G., Oben, J.A., Fusai, G. (2014). Obesity and pancreatic cancer, Surgical Oncology, 23(2),61-71. https://doi.org/10.1016/j.suronc.2014.02.003 DOI: https://doi.org/10.1016/j.suronc.2014.02.003
Renehan, A.G., Tysona, M., Egger, M., Halerz, R.F., & Zwahlen, M. (2008). Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet, 371, 569–578. https://doi.org/10.1016/S0140-6736(08)60269-X DOI: https://doi.org/10.1016/S0140-6736(08)60269-X
Saitta, C., Pollicino, T., & Raimondo, G. (2019). Obesity and liver cancer. Annals of Hepatology, 18(6), 810-815. https://doi.org/10.1016/j.aohep.2019.07.004 DOI: https://doi.org/10.1016/j.aohep.2019.07.004
Sánchez-Alcoholado, L., Ordóñez, R., Otero, A., Plaza-Andrade, I., Laborda-Illanes, A., Medina, J.A., Ramos-Molina, B., Gómez-Millán, J., & Queipo-Ortuño, M.I. (2020). Gut MicrobiotaMediated Inflammation and Gut Permeability in Patients with Obesity and Colorectal Cancer. International Journal of Molecular Sciences, 21(18), 6782. https://doi.org/10.3390/ijms21186782 DOI: https://doi.org/10.3390/ijms21186782
Schlottmann, F., Dreifuss, N. H., & Patti, M. G. (2020). Obesity and esophageal cancer: GERD, Barrett´s esophagus, and molecular carcinogenic pathways. Expert Review of Gastroenterology & Hepatology, 14(6), 425–433. https://doi.org/10.1080/17474124.2020.1764348 DOI: https://doi.org/10.1080/17474124.2020.1764348
Singh, S., Sharma, A. N., Murad, M. H., Buttar, N. S., El-Serag, H. B., Katzka, D. A., & Iyer, P. G. (2013). Central adiposity is associated with increased risk of esophageal inflammation, metaplasia, and adenocarcinoma: a systematic review and meta-analysis. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association, 11(11), 1399–1412.e7. https://doi.org/10.1016/j.cgh.2013.05.009 DOI: https://doi.org/10.1016/j.cgh.2013.05.009
Socol, C.T., Chira, A., Martinez-Sanchez, M.A., Nuñez-Sanchez, M.A., Maerescu, C.M., Mierlita, D., Rusu, A.V., Ruiz-Alcaraz, A.J., Trif, M., & Ramos-Molina, B. (2022). International Journal of Molecular Sciences, 23(9), 4713. https://doi.org/10.3390/ijms23094713 DOI: https://doi.org/10.3390/ijms23094713
Stevens, G.A., Singh, G.M., Lu, Y., Danaei, G., Lin, J.K., Finucane, M.M., Bahalim, A.N., McIntire, R.K., Gutierrez, H.R., Cowan, M., Paciorek, C.J., Farzadfar, F., Riley, L., & Ezzati, M. (2012). National, regional, and global trends in adult overweight and obesity prevalences. Population Health Metrics, 10(1), 22. https://doi.org/10.1186/1478-7954-10-22 DOI: https://doi.org/10.1186/1478-7954-10-22
Szczeklik, A., & Gajewski, P. (2020). Interna Szczeklika 2020, Kraków: MP, 1148-1152.
Vainio, H, Bianchini, F., & Vainio, H. (2002) Weight Control and Physical Activity, Obesity Reviews: an official journal of the International Association for the Study of Obesity, 3(1), 5-8. https://doi.org/10.1046/j.1467-789X.2002.00046.x DOI: https://doi.org/10.1046/j.1467-789X.2002.00046.x
Van Gaal, L.F, Mertens, I.L, & De Block, C.E. (2006). Mechanisms linking obesity with cardiovascular disease. Nature, 444, 875–880. https://doi.org/10.1038/nature05487 DOI: https://doi.org/10.1038/nature05487
Vigneri, P.G., Tirrò, E., Pennisi,, M.S., Massimino, M., Stella, S., Romano, C., & Manzella, L. (2015). The Insulin/IGF System in Colorectal Cancer Development and Resistance to Therapy, Frontiers in Oncology, 15(5), 230. https://doi.org/10.3389/fonc.2015.00230 DOI: https://doi.org/10.3389/fonc.2015.00230
Vucenik, I., & Joseph, P.S. (2012). Obesity and cancer risk: evidence, mechanisms, and recommendations, The New York Academy of Sciences. https://doi.org/10.1111/j.1749-6632.2012.06750.x DOI: https://doi.org/10.1111/j.1749-6632.2012.06750.x
Wang, T., Cai, G., Qiu, Y., Fei, N., Zhang, M., Pang, X., Jia, W., Cai, S., & Zhao, L. (2012). Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers. The ISME Journal, 6(2),320–329. https://doi.org/10.1038/ismej.2011.109 DOI: https://doi.org/10.1038/ismej.2011.109
Wojciechowska, U., Barańska, K., Michałek, I., Olasek, P., Miklewska, M., & Didkowska, J.A. (2022). Nowotwory złośliwe w Polsce w 2020 roku, Narodowy Instytut Onkologii im. Marii Curie- Skłodowskiej. Państwowy Instytut Badawczy., Krajowy rejestr nowotworów, 44-45.
World Health Organization (2009). Global health risks: mortality and burden of disease attributable to selected major risks. Geneva: World Health Organization.
Xu, M., Jung, X., Hines, O.J., M.D., Eibl, G., & Chen, Y. (2018). Obesity and Pancreatic Cancer: Overview of Epidemiology and Potential Prevention by Weight Loss, Pancreas, 47(2), 158–162. https://doi.org/10.1097/MPA.0000000000000974 DOI: https://doi.org/10.1097/MPA.0000000000000974
Yang, J., Ji, N., Xuelei, M., Yuquan, W., Yong, P., Xiawei, W. (2019). Targeting PI3K in cancer: mechanisms and advances in clinical trials, Molecular Cancer, 18, Article number: 26. https://doi.org/10.1186/s12943-019-0954-x DOI: https://doi.org/10.1186/s12943-019-0954-x
Zhang R., Li, H., Li, N. (2021). Risk factors for gastric cancer: a large-scale, population-based case-control study. Chin Med J (Engl), 134(16), 1952-1958. https://doi.org/10.1097/CM9.0000000000001652 DOI: https://doi.org/10.1097/CM9.0000000000001652
Zhang, Y. (2013). Epidemiology of esophageal cancer. World journal of gastroenterology, 19(34), 5598–5606. https://doi.org/10.3748/wjg.v19.i34.5598 DOI: https://doi.org/10.3748/wjg.v19.i34.5598
Zieliński, J. (2012). Chorobliwa otyłość jako przyczyna niewydolności oddychania, Pneumonologia i Alergologia Polska 2012, tom 80, nr 6, 555–559. https://doi.org/10.5603/ARM.27543 DOI: https://doi.org/10.5603/ARM.27543